Safety Jaquan Brisker (concussion), defensive tackle Zacch Pickens (groin) and cornerback Terell Smith (hip) did not travel with the Bears to London Monday night.
Brisker has started each of the Bears' first five games this season, registering 40 tackles, one interception, three tackles-for-loss, two pass breakups and one forced fumble.
Pickens has missed the last four games, while Smith has sat out the last two contests.
The Bears (3-2) are scheduled to face the Jaguars (1-4) Sunday at Tottenham Hotspur Stadium in London.